Know where your main shutoff is, before you need it
The single most useful thing a homeowner can know is where the main water shutoff is and that it actually works, because in a real emergency, a burst pipe or a supply line that lets go, the ability to stop the water in seconds is the difference between a mopped floor and a flooded one. Find your main shutoff now, usually where the water line enters the house, often near the water meter in the basement, and make sure everyone in the home knows where it is.
While you are there, try turning it. Older shutoff valves seize with age and mineral scale until they no longer close, which is the worst thing to discover during a leak. If yours will not turn, or turns but does not fully stop the water, that is a valve worth replacing on a calm scheduled visit rather than during an emergency. The same goes for the individual shutoffs under sinks and behind toilets and the washing machine.
